Recently, DCS Computing and its collaborators concluded the successful FP7 NanoSim project with a final review meeting in Brussels. NanoSim created an efficient and cost-effective multi-scale simulation platform based on free and open-source software. This platform connects models spanning a wide range of scales from the atomic scale through the particle and cluster scales, the industrial equipment scale and the full system scale. The established LIGGGHTS® and CFDEM®coupling packages developed and distributed by DCS Computing as well as the new ParScale and CPPPO codes are part of that platform. The resulting open source software platform is used to facilitate the rational design of second generation gas-particle CO2 capture technologies based on nano-structured materials with a particular focus on Chemical Looping Reforming (CLR). The NanoSim project is demonstrating the capabilities of this multi-scale software platform to custom design an industrial scale reactor/process in a way that most effectively leverages the superior reactivity and tailored selectivity of any specific nano-structured material.